Using Cockpit + framework on CPanel

Has anyone had experience of using Cockpit plus a framework on CPanel. The problem I am experiencing is that on a client’s own webhost on 123Reg which is running CPanel, a URL such as domain + /admin/ (or variations of the same) are giving me a 404 when my development and staging server are working perfectly with the same .htaccess. Any thoughts would be welcome to short circuit my research into the problem.